原发性高血压中醛固酮合成酶与肥胖及内皮功能的研究进展

原发性高血压(EH)是最常见的心血管疾病,我国目前已有患病者达2亿以上。其发生可能与遗传、饮食、肥胖等多种因素相关。肾素-血管紧张素-醛固酮系统(RAAS)激活、水钠潴留、内皮功能异常及交感神经系统活性亢进等危险因素,最终导致血压升高。醛固酮合成酶CYP11B2是醛固酮合成最后的关键性酶,CYP11B2基因-344C/T多态性影响醛固酮的表达。研究发现脂肪组织有存在决定醛固酮合成的关键酶——CYP11B2,同时检测到醛固酮的表达。已知一氧化氮合酶(eNOS)基因和CYP11B2在高血压作用机制上有一定的联系,二者在高血压发病机制中都起调节作用。本文综述了在EH中醛固酮合成酶与肥胖及内皮功能相关的研究进展。

The Research of Aldosterone Synthase,Obesity and Endothelial Function in Essential Hypertension

Essential hypertension(EH) is the most common cardiovascular disease,the number of the patients has reached more than 200 million in China at present.Its occurrence may be related to genetics,diet,obesity and other factors.There are some risk factors that lead to high blood pressure eventually Including Renin-angiotensin-aldosterone system(RAAS) activation,water and sodium retention,dysfunction of endodermis and hyperactivity of sympathetic nervous system,etc.Aldosterone synthaseCYP11B2 is the final key enzyme of aldosterone synthesis,CYP11B2 gene-344 C/T polymorphism influence the expression of aldosterone.The study finds that fat tissue determines the key enzyme-CYP11B2 of aldosterone synthesis and the expression of aldosterone could be detected from it.It is known that there is some connection between Nitric oxide synthase(eNOS) gene and CYP11B2 in the pathogenesis of hypertension,both of them play a regulatory role in the hypertension pathogenesis.This article summarized the related research progress on aldosterone synthase,obesity and endothelial function in essential hypertension.