胺碘酮与苯那普利联合治疗对阵发性房颤复发率等的影响

目的评价ACEI制剂苯那普利（洛汀新）与小剂量胺碘酮联合治疗对减少阵发性心房颤动（房颤）复发率的作用。方法将有完整资料的共46例阵发性心房颤动（房颤）患者根据用药情况分为胺碘酮组（1组，n=22）、胺碘酮＋苯那普利组（Ⅱ组2，n=24），治疗随访时间为1年，比较两种治疗方法对阵发性心房颤动患者窦性心律维持率的影响以及治疗前、治疗后12个月左心房内径大小的变化。结果治疗12个月后，Ⅰ组窦性心律维持率为59．09％．Ⅱ组窦性心律维持率为83．33％。即Ⅰ组明显低于Ⅱ组（P〈0．05）；而且Ⅰ组左心房内径大小的变化（治疗前左心房内径34．28±1．54mm；治疗后为38．48±1．68mm），大于Ⅱ组（治疗前左心房内径为34．68±1．56mm；治疗后为35．28±1．42mm）（P〈0．05）。结论小剂量胺碘酮联合苯那普利对阵发性房颤的治疗，在窦性心律的维持、抑制左心房的扩大方面均优于单用胺碘酮．

Clinical Efficacy of Benazepril Combination Therapy with Low-dose Amiodarone in Patients with Paroxysmal Atrial Fibrillation

Objective To investigate whether benazepril in combination with low-dose amiodarone is more effective than amiodarone alone on maintenance of sinus rhythm （reduce recurrence rate） and to inhibit the enlargement of left atrium in patients with paroxysmal atrial fibrillation （PAF）.Methods A retrospective study was carried out in patients with paroxysmal atrial fibrillation from January 2002 to October 2007.Forty-six patients with PAF were included in the study and divided into two groups：group Ⅰ （amiodarone group,n=22） wes treated with amiodarone alone, group Ⅱ （amiodarone plus benazepril group,n=24） was treated with amiodarone and benazepril in combination. The left atrial diameter （LAD） was measured with transthoracic echocardiogram at before and after 12-month of treatment.The duration of observation was up to one year and the primary end point of the study was the first recurrence olAF.Comparing the effect of the two therapies on PAF.Results After 12 months,the maintenance of sinus rhythm in group Ⅱ was higher significantly than in group Ⅰ （83.33% vs 59.09%,P〈0.05）,and LAD in group Ⅰ was significantly larger than group Ⅱ （P〈0.05）.Conelusions The results of this study suggest that the combination of amiodarone with angiotensin converting enzyme inhibitor benazepril is more effective than amiodarone alone in the maintenance of sinus rhythm for idiopathic PAF and can inhibit the enlargement of left atrium in patients with PAF.