液基细胞学在经支气管镜针吸细胞学诊断肺癌中的价值

目的探讨液基细胞学技术（thin prep cytology test,TCT）在中央型肺癌针吸细胞学诊断中的价值。方法分析127例中央型肺癌患者的经支气管针吸活检（transbronchial needle aspiration,TBNA）标本,随机将患者分为常规涂片（conventional smear,CS）组及CS联合TCT组,其中CS组62例,CS＋TCT组65例。比较两组方法的敏感性及特异性。结果 CS组的敏感性为75.9%,特异性为100.0%;CS＋TCT组的敏感性为96.2%,特异性为100.0%。与CS组相比,CS＋TCT组的敏感性明显高于CS组（P=0.000046〈0.01）。结论联合使用CS＋TCT能提高中央型肺癌针吸细胞学的敏感性,TBNA的TCT检测法可推广应用于临床。

Evaluation of thin prep cytology test in transbronchial needle aspiration for diagnosis of lung cancer

Objective To explore the diagnostic value of thin prep cytology test（TCT） in central lung cancer. Methods All 127 patients suspected central lung cancer were detected by transbronchial needle aspiration（TBNA）. The patients were randomly assigned into two groups, the group of conventional smear,CS（62 cases） and the group of CS＋TCT（65cases）. The sensitivity and specificity of two methods were compared. Results The sensitivity and specificity of CS were 75.9% and 100.0% respectively. The sensitivity and specificity of CS＋TCT were 96.2% and 100.0% respectively.The sensitivity of CS＋TCT was significantly higher than sensitivity of CS in diagnosis of lung cancer（P=0.0000460.01）. Conclusion Combination of CS and TCT techniques can improve the TBNA diagnostic sensitivity of lung cancer.TBNA-TCT detection methods should be applied to clinical activites.