阿立哌唑与利培酮对精神分裂症患者的临床疗效及认知功能的影响

目的探讨阿立哌唑与利培酮对精神分裂症患者的临床疗效及认知功能的影响。方法选择150例精神分裂症患者随机分为A组和B组,每组75例,A组给予阿立哌唑口服,B组给予利培酮口服,治疗4、8、12周采用阳性与阴性症状量表（PANSS）、可重复成套神经心理状态测验（RBANS）评价疗效及认知功能。结果两组干预4、8、12周PANSS量表阳性症状、阴性症状、一般精神病理及总分均显著降低（P〈0.05）,A组干预12周阴性症状评分显著低于B组（P〈0.05）,余各时段两组各项评分均无显著性差异（P〉0.05）。两组干预4、8、12周RBANS量表即刻记忆、视觉空间结构、语言、注意、延迟记忆及总分均显著提高（P〈0.05）,A组干预12周总分显著高于B组（P〈0.05）,余各时段两组各项评分均无显著性差异（P〉0.05）。两组患者出现的不良反应程度轻微,A组体重增加、锥体外系反应发生率显著低于B组（P〈0.05）,余各项不良反应发生率均无显著性差异（P〉0.05）。结论阿立哌唑与利培酮治疗精神分裂症有相当的临床效果,均可显著改善症状,阿立哌唑改善认知功能的效果更优,安全性高。

Effect of aripiprazole and risperidone on clinical efficacy and cognitive function in patients with schizophrenia

Objective To investigate the effects of aripiprazole and risperidone on clinical efficacy and cognitive function in patients with schizophrenia. Methods A total of 150 cases of schizophrenia were randomly divided into group A and group B（n=75）, A group was given oral aripiprazole, group B was given oral risperidone,received treatment 4,8,12 weeks, PANSS, RBANS evaluate the efficacy and cognitive function. Results The intervention 4, 8, 12 weeks the PANSS positive symptoms, negative symptoms and general psychopathology scores were significantly lower（P〈0.05）, A group of 12 weeks negative symptom scores were significantly lower than group B （P〈0.05）, more than two entries each time scores were not significantly different（P〉0.05）. RBANS scale intervention groups 4, 8, 12 weeks immediately vulnerable, visual spatial structure, language, attention, memory latency and total scores were signifieafitly increased （P〈0.05）, A group of 12 weeks total score were significantly higher than in group B（P〈0.05）, more than two entries each time scores were not significantly different （P〉O.05）. Adverse reactions in patients with mild degree of both groups, A group of weight gain, extrapyramidal reactions were significantly lower than in group B （P〈0.05）, more than the incidence of adverse reactions were no significant difference（P〉0.05）. Conclusion Aripiprazole and risperidone in the treatment of schizophrenia have considerable clinical effect, could significantly improve symptoms, aripiprazole ef- fect of improving cognitive function better and safe.