血清25-（OH）D和总免疫球蛋白E水平与儿童反复性肺炎的关系

目的探讨血清25-（OH）D和总免疫球蛋白E（TIgE）与无明确基础疾病儿童反复性肺炎的关系。方法选取76例无明确基础疾病反复性肺炎及72例单次肺炎患儿作为观察组,儿童保健门诊体检的60名儿童作为对照组,测定三组血清25-（OH）D及总免疫球蛋白E（TIgE）含量。结果反复肺炎组血清25-（OH）D水平明显低于单次肺炎组和对照组,差异有统计学意义（P〈0.05）,单次肺炎组血清25-（OH）D和对照组比较,差异无统计学意义（P〉0.05）;反复肺炎组血清TIgE含量水平高于单次肺炎组和对照组（P〈0.05）,单次肺炎组和对照组血清TIgE比较,差异无统计学意义（P〉0.05）。结论维生素D缺乏可能是儿童患反复肺炎的诱因之一,在临床应加强儿童维生素D缺乏的预防、诊断和治疗。

Relationship between serum 25-hydroxy vitamin D and total IgE levels in children with recurrent pneumonia

Objective To study the relationship of serum 25-hydroxy vitaminD and total IgE levels in children with recurrent Pneumonia but no underlying diseases. Methods Seventy-six children with recurrent pneumonia but no underlying diseases and seventy-two children with single pneumonia who visited the hospital were divided into lob servation group. Sixty health examination children in child health clinic as a tontrol group. The levels of 25-hydroxy-vitamin D and total IgE were compared. Results Serum 25-hydroxy-vitamin D levels were significantly lower in the re current pneumonia group than those in a single pneumonia group and control group, the differences were statistically significant（P〉0.05）. Serum 25-hydroxy-vitamin D levels in the a single pneumonia group were lower than those in control group, but the difference were no statistically significant（P〈0.05）. Serum TIgE levels were significantly higher in the recurrent pneumonia group than those in the single pneumonia group and control group, the differences were statistically significant（P〈0.05）. Serum TIgE levels in single pneumonia and control, the differences were not statistically significant（P〉0.05）. Conclusion Vitamin D deficiency may be one of the factors for recurrent Pneumonia in children, attention should be paid in clinic to strengthen the prevention, diagnosis and treatment of vitamin D deficiency.