莫沙必利联合多潘立酮治疗功能性消化不良的临床疗效观察

目的：观察莫沙必利联合多潘立酮治疗功能性消化不良的临床疗效。方法选择我院2011年6月-2014年1月收治的120例FD患者，全部患者随机分为观察组和对照组，每组各60例，对照组予多潘立酮口服，10 mg/次，3次/d，饭前半小时服用，连用2周。观察组同时联合莫沙必利口服，5 mg/次，3次/d，饭前半小时服用，连用2周。治疗期间密切观察及记录可能出现的不良反应。比较两组的疗效及治疗前后临床症状积分、复发率。结果观察组和对照组患者治疗后的总有效率分别为93.3%、78.3%，差异具有统计学意义（χ2=6.273，P〈0.05）。两组患者的上腹痛或不适、上腹饱胀、早饱、嗳气等临床症状积分治疗后均较治疗前显著降低，且观察组显著低于对照组，差异有统计学意义（P〈0.05）。治疗3个月后对两组患者进行随访，观察组共随访52例，对照组共随访50例，其中观察组复发6例，对照组复发14例，两组复发率比较，差异具有统计学意义（χ2=5.137，P〈0.05）。结论莫沙必利联合多潘立酮治疗功能性消化不良可以提高疗效，明显改善患者的临床症状，降低复发率，值得推广和应用。

The clinical efficacy of mosapride joint domperidone in treatment of functional dyspepsia

Objective To observe the clinical efficacy of mosapride joint domperidone in treatment of functional dys-pepsia. Methods In our hospital,from June 2011 to January 2014, seleceted 120 FD patients were randomly divided into observation group and control group,60 cases in each group,the control group took domperidone oral,10 mg/time,3 times/d, took half an hour before meals, once every two weeks. Meanwhile study group combined mosapride oral,5 mg/time, 3 times/d, took half an hour before meals, once every two weeks. Closely observed and recorded adverse reactions during treatment. Results The total efficiency of the study group and control group after treatment was 93.3%,78.3%, the difference was statistically significant between two groups （χ2= 6.273,P〈0.05）. The observation group and the control group of patients with abdominal pain or discomfort, bloating, early satiety, belching and other clinical symptom score after treatment was significantly lower than before treatment,and the observation group was sig-nificantly lower than the control group＇s the difference was statistically significanct between two groups （P〈0.05）. After treatment 3 months, two groups patients were followed＇s the observation group were followed up 52 cases,the control group were followed up for 50 cases, 6 cases of relapse of the observation group, the control group had 14 cases of re-currence,the difference of the recurrence rate was statistically significant between the two groups（χ2=5.137,P〈0.05）. Conclusion Mosapride joint domperidone in treatment of functional dyspepsia can improve efficacy, improve detailed clinical symptoms,reduce the relapse rate,worthy of promotion and application.