心力衰竭患者血清可溶性ST2受体的变化及意义

目的测定心力衰竭患者不同时间点的血清可溶性ST2受体浓度，分析其在心力衰竭早期诊断及病情评估方面的意义。方法选择心力衰竭患者60例作为实验组，对照组60例。评价其心功能情况及临床变化。ELISA法测定患者入院时、第3天血清可溶性ST2受体水平、N-末端脑利钠肽前体及测定入院时的左室射血分数。结果实验组血清可溶性ST2受体（sST2）水平显著高于对照组，左心室射血分数显著低于对照组，差异均有统计学意义（P〈0．05）。血清可溶性ST2受体（sST2）水平与N一末端脑利钠肽前体呈正相关（P〈0．01），与左心室射血分数（LVEF）呈负相关（P〈0．01）。结论血清可溶性ST2受体（sST2）浓度可以作为判断患者有无心力衰竭的实用指标，并且对于心力衰竭严重程度的判断有重要的指导意义，指导临床诊断及治疗。由于sST2浓度与LVEF值呈负相关，有望通过sST2浓度来预测患者的LVEF值。

The changes and significance of soluble ST2 receptor in heart failure patients

Objective To determine concentrations of serum soluble ST2 receptors（sST2） of patients with heart failure at different time points and analyze its significance in early diagnosis and Condition assessment of heart failure. Methods Sixty patients with heart failure were taken as the experiment group and 60 people without heart failure were taken as the control group. Their cardiac function and clinical changes were evaluated. The ELISA method was used to measure the serum soluble ST2 receptors concentration on admission and on the 3th day and measure left ventricular ejection fraction（LVEF）and N-terminal pro-brain natriuretic peptide precursors（NT-proBNP）. Results The experment group was significantly higher than the control group in the serum sST2 level and was significantly lower in theLVEF, with statistically significant difference （P〈0.05）. The sST2 concentration and NT-proBNP value was positively correlated （P〈 0.01 ）,and was negative correlation with the left ventricular ejection fraction（P〈0.01 ）. Conclusion Serum sST2 concentration can be used as a judge whether there arc heart failure patients with sensitive index, and can be used to judge the severity of heart failure, because the sST2 concentration and LVEF value is negatively correlated, is expected to through the sST2 concentration to predict the patients LVEF value.