动态血糖监测系统对2型糖尿病患者血糖漂移的影响

目的观察动态监测2型糖尿病（T2DM）患者血糖漂移的细节及波动趋势,为合理的治疗方案提供临床依据。方法采用动态血糖监测系统（CGMS）对86例T2DM患者进行72 h动态血糖监测,并对第1日及第3日评估参数进行分析。结果 24 h平均血糖水平（24 h MBG）由胰岛素剂量调整前的（10.7±2.7）mmol/L降至（7.9±1.6）mmol/L（P〈0.05）;调整后日内平均血糖波动幅度（MAGE）由（5.5±1.6）mmol/L降至（2.3±1.0）mmol/L（P〈0.05）;胰岛素剂量调整前后血糖的时间百分比均明显下降,PT1（≤3.9 mmol/L）由0.8%降至0.3%,PT3（≥7.8mmol/L）由（32.7±7.5）%降至（14.7±3.1）%（P〈0.05）;血糖低于5 mmol/L的平均发生次数由1.6次降至0.7次（P〈0.05）。结论动态血糖监测系统能详细地显示T2DM患者血糖漂移的幅度和趋势,辅助临床医师制定更为针对性的降糖方案,有效控制血糖波动和低血糖的发生,缩短住院时间。

The efficacy of glucose excursion by the continuous glucose monitors system in the patients with type 2 diabetes

Objective To explore the efficacy of glucose excursion by the continuous glucose monitors system（CGMS）in the patients of type 2 diabetes. Methods A total of 86 T2 DM cases were enrolled. All patients were observed with CGMS for 72 hours. All the indexes were compared between the first day and the third day. Results The 24 h average blood glucose（24 h MBG） levels by insulin dose tendency reduced from（10.7±2.7） mmol/L to（7.9±1.6） mmol/L before the adjustment tendency（P 0.05）; Adjusted days average blood glucose fluctuation（MAGE） tendency reduced from（5.5±1.6）mmol/L to（2.3±1.0） mmol/L tendency（P 0.05）; Insulin dose before and after the adjustment blood glucose were significantly decreased as a percentage of the time of PT1（≤3.9 mmol/L tendency）reduced from 0.8% to 0.3%, the PT3（≥7.8 mmol/L tendency） reduced from（32.7±7.5）% to（14.7±3.1）%（P〈0.05）; Blood sugar lower than 5 mmol/L tendency for the average frequency reduced from 1.6 times to 0.7 times（P〈0.05）. Conclusion Dynamic blood sugar monitoring system can display the extent of T2 DM patients blood sugar drift in detail and the trend of more targeted hypoglycemic auxiliary clinician, effective control of blood glucose fluctuation and the occurrence of hypoglycemia,shorten hospitalization time.