应用咪达唑仑与右美托咪定的镇静效果比较

目的探究重症监护室中应用咪达唑仑与右美托咪定的镇静效果。方法将我院ICU收治的100例行机械通气患者,随机分成A、B两组,每组50例,A组使用咪达唑仑镇静,B组使用右美托咪定镇静,比较两组患者的镇静效果。结果 A组患者达镇静满意时间显著短于B组患者（P〈0.05）,而A组的不良反应发生率、停药后唤醒所需时间均显著高于B组（P均〈0.05）;A组患者的镇静满意率显著低于B组（P〈0.05）。结论右美托咪定应用于重症监护室患者起效较慢,但唤醒时间短、不良反应发生率低、镇静满意度高。

Comparison of midazolam and dexmedetomidine on the effect of sedation

Objective To explore the sedative effects of midazolam and dexmedetomidine in the intensive care unit. Methods A total of 100 patients admitted in our hospital ICU mechanical ventilation were randomly divided into A, B two groups, each group of 50 cases, group A received midazolam treatment, while group B received the dexmedetomi- dine treatment, the sedative effect were compared between two groups of patients. Results The time that patients of group A needed to reach calm satisfaction was significantly shorter than group B patients（P〈0.05）, and the incidence of adverse reaction, the time needed for withdrawal after wake up of group A was both significantly higher than group B respectively（P〈0.05）; Group A＇s calm satisfaction rate was significantly lower than group B（P〈0.05）. Conclusion Dexmedetomidine used in ICU patients with slow onset, but the wake-up time is short, with low incidence of adverse reactions and sedation high satisfaction.