青岛市552例妊娠合并尿路感染病原菌及其药物敏感性分析

目的：了解青岛市妊娠合并尿路感染患者的病原菌分布及耐药性。方法对552例妊娠合并尿路感染的患者进行中段尿培养及药物敏感分析。结果大肠埃希菌、屎肠球菌、鲍曼不动杆菌为妊娠合并尿路感染病原菌的前三位，大肠埃希菌对哌拉西林他唑巴坦、亚胺培南、阿米卡星、头孢哌酮舒巴坦和呋喃妥因均保持较低的耐药率，分别为1.99%、1.49%、4.47%、2.98%和3.98%，对环丙沙星、左氧氟沙星耐药率均较高，分别为73.13%和67.16%。结论妊娠合并尿路感染的病原菌谱和耐药率已经发生变化，须注意监测中段尿的病原菌及其耐药菌谱，为临床治疗提供用药参考。

Analysis on the pathogenic bacteria and their drug susceptibility in 552 cases of pregnancy combined with urinary tract infection in Qingdao

Objective To investigate the distribution and drug resistance of pathogenic bacteria in patients with preg-nancy combined with urinary tract infection. Methods Mid-stream urine culture and drug susceptibility analysis were conducted on 552 patients with pregnancy combined with urinary tract infection. Results The top 3 pathogenic bacteria for pregnancy combined with urinary tract infection were escherichia coli, enterococcus faecium and acinetobacter bau-mannii. Escherichia coli remained low resistance rate to piperacillin-tazobactam （1.99%）, imipenem （1.49%）, amikacin （4.47%）, cefperazone-sulbactam （2.98%） and macrodantin （3.98%）, but high resistance rate to ciprofloxacin （73.13%） and levofloxacin （67.16%）. Conclusion The spectrum and drug resistance rate of pathogenic bacteria in pregnancy combined with urinary tract infection are changing. The pathogenic bacteria in urine and their drug resistance should be closely monitored to provide reference for clinical drug use.