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宫颈上皮内瘤变及宫颈癌中TS、PCNA的表达及其意义
引用本文:郑巧荣,崔金全.宫颈上皮内瘤变及宫颈癌中TS、PCNA的表达及其意义[J].中国妇幼保健,2011,26(7):1083-1085.
作者姓名:郑巧荣  崔金全
作者单位:1. 河南职工医学院妇产科教研室,河南,郑州,450000
2. 郑州大学第二附属医院妇产科
摘    要:目的:探讨胸苷酸合成酶(thymidylate synthase,TS)在宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)及宫颈癌发生、发展中的作用及与预后的关系。方法:采用免疫组化SP法检测TS、增殖细胞核抗原(proliferating cell nuclearantigen,PCNA)在慢性宫颈炎、宫颈上皮内瘤变及宫颈癌中的表达。结果:与慢性宫颈炎相比,CIN及宫颈癌中TS的表达率明显增高(P值分别为0.006、0.004);而CIN与宫颈癌组比较,差异无统计学意义(P=0.780);CIN各组之间差异亦无显著性。在宫颈癌中,TS的表达与临床分期、淋巴结转移有关(P值分别为0.033、0.015),与细胞分化程度及肌层浸润深度无关(P值分别为0.343、0.350)。PCNA在CIN和宫颈癌中的表达率明显高于慢性宫颈炎(P值分别为0.029、0.000),在宫颈癌中的表达率也明显高于CIN(P值为0.000)。在CIN和宫颈癌中,TS和PCNA的表达存在关联性(Pearson列联系数=0.319 6,χ2=8.371,P<0.005)。结论:TS作为一种促细胞增殖的蛋白与宫颈病变的发生有一定关系,对预测宫颈癌的预后有一定参考价值。

关 键 词:宫颈上皮内瘤变  宫颈癌  胸苷酸合成酶  增殖细胞核抗原

Expressions and clinical significances of TS and PCNA in cervical intraepithelial neoplasia and cervical carcinoma
ZHENG Qiao-Rong,CUI Jin-Quan.Expressions and clinical significances of TS and PCNA in cervical intraepithelial neoplasia and cervical carcinoma[J].Maternal and Child Health Care of China,2011,26(7):1083-1085.
Authors:ZHENG Qiao-Rong  CUI Jin-Quan
Institution:ZHENG Qiao-Rong,CUI Jin-Quan.Department of Obstetrics and Gynecology,Henan Staff Medical College,Zhengzhou 450000,Henan,China
Abstract:Objective:To explore the role of thymidylate synthase(TS) in occurrence and development of cervical intraepithelial neoplasia(CIN) and cervical carcinoma and its relationship with prognosis. Methods:Immunohistochemical SP method was used to detect the expression levels of TS and proliferating cell nuclear antigen(PCNA) in chronic cervicitis,CIN and cervical carcinoma. Results:Compared with chronic cervicitis group,the expression rates of TS in CIN group and cervical carcinoma group increased significantly(P...
Keywords:Cervical intraepithelial neoplasia  Cervical carcinoma  Thymidylate synthase  Proliferating cell nuclear antigen  
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