多囊卵巢综合征患者血浆内脂素水平的变化及意义

目的:探讨多囊卵巢综合征(PCOS)患者血浆内脂素水平的变化及意义。方法:采用酶联免疫吸附法测定50例PCOS患者和45例健康体检者血浆内脂素水平,采用化学发光法测定空腹胰岛素(FINS)和血清性激素水平,采用葡萄糖氧化酶法测定空腹血糖(FPG)水平,并分析血浆内脂素水平与体重指数(BMI)、腰臀比(WHR)、空腹血糖、空腹胰岛素、胰岛素抵抗指数(HOMA-IR)和血清性激素的关系。结果:①PCOS组血浆内脂素水平为(21.18±4.31)ng/ml,对照组为(12.47±3.38)ng/ml,两组相比有统计学差异(P<0.01);肥胖PCOS组血浆内脂素水平为(22.10±5.20)ng/ml,非肥胖P-COS组为(20.39±3.27)ng/ml,分别高于肥胖对照组(14.68±3.02)ng/ml及非肥胖对照组(10.71±2.53)ng/mL(P<0.01)。②相关性分析显示,PCOS组血浆内脂素水平与WHR(r=0.43,P<0.01)、HOMA-IR(r=0.55,P<0.01)呈正相关。结论:PCOS患者血浆内脂素水平升高;血浆内脂素水平与胰岛素抵抗、肥胖呈正相关。

The change of plasma visfatin level in women with polycystic ovary syndrome

Objective:To investigate plasma visfatin level in women with polycystic ovary syndrome(PCOS) and to explore the significance of visfatin in PCOS. Methods:Plasma visfatin levels of fifty women with PCOS and forty-five healthy women were detected by enzyme linked immunosorbent assay(ELISA) method,insulin and serum sexual hormone by electrochemiluminescence immunoassay method,fasting plasma glucose by glucose oxidation enzyme method.To analyze the relationships of visfatin to body mass index(BMI),waist to hip ratio(WHR),fasting plasma glucose(FPG),fasting insulin(FINS),insulin resistance index and the levels of serum sexual hormones. Results:①The plasma visfatin levels were elevated in PCOS group((21.18±4.31) ng/mL vs(12.47±3.38) ng/mL,P<0.01) when compared with normal controls.Plasma visfatin levels of PCOS obese group was(22.10±5.20) ng/mL,of PCOS non-obese group was(20.39±3.27) ng/mL.Their values were higher than obese control group((14.68±3.02) ng/mL),and non-obese control group((10.71±2.53) ng/mL)(P<0.01).②Plasma visfatin level was positively correlated with WHR(r=0.43,P<0.01),HOMA-IR(r=0.55,P<0.01) in PCOS group. Conclusion:The women with PCOS exhibite higher plasma visfatin levels than control subjects.Plasma visfatin level is correlated with insulin resistance and obesity.