重组人干扰素α-2a治疗宫颈高危型人乳头瘤病毒感染疗效观察

目的:探讨重组人干扰素α-2a(商品名淑润栓)治疗宫颈高危型人乳头瘤病毒(hr-HPV)感染的临床疗效。方法:将306例宫颈hr-HPV感染者随机分为两组,治疗组用重组人干扰素栓α-2a阴道用药,对照组仅用生理盐水冲洗,检测6个月后hr-HPV有无转阴。结果:治疗组、对照组hr-HPV的转阴率分别为75.16%、13.73%,两组比较差异有统计学意义(P<0.01)。结论:重组人干扰素栓α-2a治疗宫颈hr-HPV感染局部用药简单方便,疗效肯定,耐受性好,安全性高。

Observation on the therapeutic effect of recombinant human interferon a-2a in treatment of cervical high risk human papillomavirus infection

Objective:To explore the therapeutic effect of recombinant human interferon α-2a in treatment of cervical high risk human papillomavirus(HPV) infection.Methods:306 cases with cervical high risk HPV infection were divided into two groups randomly,the cases in treatment group were treated with recombinant human interferon α-2a by vaginal administration,the cases in control group were treated with normal saline by vaginal flushing,the negative conversion rates of high risk HPV after 6 months in the two groups were detected.Results:The negative conversion rates of high risk HPV in treatment group and control group were 75.16% and 13.73%,respectively,there was significant difference between the two groups(P<0.01).Conclusion:Recombinant human interferon α-2a is simple,convenient,effective,tolerant and safe in treatment of cervical high risk HPV infection.