乙型肝病患者细胞因子和T细胞亚群的变化

目的：研究慢性肝炎和肝硬化患者血清细胞因子IL－2、INF－γ、IL－6、IL－10与T细胞亚群的变化及临床意义。方法：ELISA流式细胞术。结果：慢性肝炎活动期组可见CD4^＋细胞数升高和CD8^＋细胞数呈上升趋式势和Th1型细胞因子IL－2、INF－γ较显著升高，肝硬化组呈明显的CD4^＋细胞数减少。同时，Th1型细胞因子IL－2、INF－γ与Th2型细胞因子IL－6，IL－10均显著增高，且细胞因子的上升程度与疾病的严重程度基本平行。结论：CD8^＋细胞数和Th1型细胞因子上升与急性炎症反应有较密切关系，而CD^＋细胞数和Th1型细胞因子、Th2型细胞因子升高是肝硬化免疫反应的特征之一，因此通过对细胞因子和T细胞亚群的测定可以帮助我们鉴别各类肝病和把握病情。

The Changes Of Serum Cytokine And T Lymphocyte Subsets In Patients With Liver Diseases

Objective To investigate the changes of serum cytokine and T lymphocyte subsets and their clinical significance in patients with HBV hepatitie.Methods ELISA and FCM.Results The CD8+ T cells and Th1 type cytokine were higher in patients with severe viral hepatitis,The CD4+T cells and both Th1 type cytokine and Th2 type cytokine were markly increased in patients with cirrohosis.Conclusion For the clinical distinguishing various liver diseases,determination of levels of serum cytokine and T lymphocyte subsets may be particularly useful.