乙型、戊型肝炎病毒重叠感染107例分析

目的: 了解乙型肝炎病毒重叠戊型肝炎病毒感染的临床特点。方法: 回顾性总结不同年龄组、HBeAg阴阳性组乙型肝炎病毒重叠戊型肝炎病毒感染的临床资料。结果: 107例乙型肝炎病毒重叠戊型肝炎病毒感染中,乙、戊型肝炎重叠感染各年龄组丙氨酸氨基转移酶(ALT)、凝血酶原时间(PT)、血小板计数(BPC)和总胆红素(TBIL)差异均无显著性(P>0.05),但A/G、WBC差异均有显著性(P<0.01和P<0.05),而且高年龄组的病死率明显高于低年龄组(P<0.005);HBeAg阳性组与HBeAg阴性组之间ALT、TBIL、A/G、WBC和BPC差异均无显著性(P>0.05),而两组PT间差异有显著性(P<0.05)。HBeAg阴性组、HBeAg血清转换组的病死率与HBeAg阳性组差异均无显著性(P>0.05)。结论: 在乙型肝炎病毒重叠戊型肝炎病毒感染患者中,高年龄患者病死率高。HBeAg阴性的乙型肝炎病毒可能比HBeAg阳性乙型肝炎病毒更易重叠感染戊型肝炎病毒。

Hepatitis B virus superinfection hepatitis E virus:Analysis of 107 cases

Objective: To explore the clinical features of hepatitis B virus superinfection hepatitis E virus.Methods: The clinical datas of different age groups and HBeAg(+) or (-) groups of which hepatitis B virus superinfected hepatitis E virus were analyzed retrospectively.Results: In 107 patients:no significant differences in the levels of ALT、PT、BPC and TBIL were found in different age groups(P>0.05),but there were significant differences in the level of A/G and WBC(P<0.01 and P<0.05).Moreover the mortality of the old age group was higher than the youth age groups(P<0.005).No significant differences in the levels of ALT、TBIL、A/G、WBC and BPC were found in HBeAg(+) or (-) groups (P>0.05),however,the levels of PT were significant different between two groups(P<0.05),the mortalities among HBeAg(-)、HBeAg seroconversion and HBeAg(+) group were not significant different(P>0.05).Conclusions: The mortality of the old age patients is highest among patients in which hepatitis B virus superinfected hepatitis E virus.Hepatitis B virus which is HBeAg(-) may be easier superinfected hepatitis E virus than hepatitis B virus which is HBeAg(+).