| 胰岛素微粒剂的制备、含量、包裹率与生物活性稳定性 |
| |
| 引用本文： | 王思玲,苏德森,顾学裘.胰岛素微粒剂的制备、含量、包裹率与生物活性稳定性[J].沈阳药科大学学报,2000,17(1):23-25. |
| |
| 作者姓名： | 王思玲 苏德森 顾学裘 |
| |
| 作者单位： | 沈阳药科大学药学系,沈阳,110015 |
| |
| 摘 要： | 采用生物效价与放射免疫分析两种方法对微粒剂胰岛素含量进行测定．通过胰岛素放射免疫活性分析测定了胰岛素包裹率．以胰岛素生物效价为指标，采用恒温加速实验考察了微粒剂的生物活性稳定性，结果表明：微粒剂胰岛素含量分别为０－５１ｕ／ｍｇ 与０－５５ＩＵ／ｍｇ；包裹率在９０ ％以上；室温放置１ 年，未见生物活性明显改变；２５ ℃生物活性有效期为１２－５ 月．
|
| 关 键 词： | 胰岛素微粒剂 生物效价 放射免疫分析 包裹率 稳定性 |
| 修稿时间： | 1999-05-17 |
Studies on the Preparation,the Contents,the Encapsulation Efficiencies and the Bioactive Stabilities of Insulin Microparticles(INS-MP) |
| |
| Wang Siling,Su Desen,Gu Xueqiu.Studies on the Preparation,the Contents,the Encapsulation Efficiencies and the Bioactive Stabilities of Insulin Microparticles(INS-MP)[J].Journal of Shenyang Pharmaceutical University,2000,17(1):23-25. |
| |
| Authors: | Wang Siling Su Desen Gu Xueqiu |
| |
| Abstract: | The contents of INS MP were measured by the method of the insulin biopotency and radioimmunoassay(RIA).The encapsulation efficiency was determined to be over 90% according to the RIA.By taking the biopotency as an index and using accelerated tests,the bioactive stabilities were determined.The contents were 0.51 u/mg and 0.55 IU/mg and the bioactivity at 25℃ was valid for 12.5 months. |
| |
| Keywords: | insulin microparticles biopotency radioimmunoassay encapsulation efficiency stability |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
