Future possibilities in the prevention of breast cancer: Role of genetic variation in breast cancer prevention |
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Authors: | HeatherSpencer Feigelson BrianE Henderson |
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Affiliation: | (1) American Cancer Society, Atlanta, Georgia;(2) University of Southern California, Los Angeles, California, USA; |
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Abstract: | Risk factors for breast cancer are related to endogenous hormonesand reproductive events. As such, traditional cancer prevention strategies arenot easily applicable. Tamoxifen and other selective estrogen receptormodulators (SERMs) offer a new preventive strategy for some high-risk women,but have not yet been shown to be efficacious for all women. New tools toidentify high-risk women are needed. One such tool is the development of amultigenic model of breast cancer susceptibility that can be used to screenwomen in order to identify those who carry a combination of alleles that putsthem at significantly increased risk. |
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