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| 肾移植患者MDR1C3435T基因多态性对他克莫司血药浓度/剂量比及疗效的影响 | |
| 引用本文： | 侯明明,宋洪涛,王庆华,杨顺良,谭建明.肾移植患者MDR1C3435T基因多态性对他克莫司血药浓度/剂量比及疗效的影响[J].药学实践杂志,2010,28(1):29-31. |
| 作者姓名： | 侯明明 宋洪涛 王庆华 杨顺良 谭建明 |
| 作者单位： | 1. 南京军区福州总医院药学科,福建福州,350025;沈阳药科大学药学院,辽宁,沈阳,110016 2. 南京军区福州总医院药学科,福建福州,350025 3. 南京军区福州总医院泌尿外科,福建,福州350025 |
| 摘 要： | 目的研究肾移植术后患者MDR1C3435T基因多态性对他克莫司（FK506）血药浓度／剂量比（C／D）及急性排斥反应和不良反应的影响。方法采用聚合酶链反应（PCR）和限制性内切片段长度多态性（RFLP）的方法检测肾移植患者MDR1C3435T基因型，比较不同基因型患者之间FK506的C／D值以及急性排斥反应、不良反应的差异。结果MDR1C3435T各基因型组间FK506的C／D值及急性排斥反应、不良反应均无显著性差异。结论MDR1C3435T基因多态性与肾移植患者FK506的C／D值及急性排斥反应、不良反应间无显著相关性。 |
| 关 键 词： | 肾移植 他克莫司 MDR1 基因多态性 血药浓度／剂量比 疗效 不良反应 |
| 收稿时间： | 2009/6/29 0:00:00 |
| 修稿时间： | 2009/8/18 0:00:00 |
Effect of MDR1C3435T genetic polymorphism on concentration/dose and efficacy of tacrolimus in patients with kidney transplantation |
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| HOU Ming-ming,SONG Hong-tao,WANG Qing-hu,YANG Shun-liang and TAN Jian-ming.Effect of MDR1C3435T genetic polymorphism on concentration/dose and efficacy of tacrolimus in patients with kidney transplantation[J].The Journal of Pharmaceutical Practice,2010,28(1):29-31. | |
| Authors: | HOU Ming-ming SONG Hong-tao WANG Qing-hu YANG Shun-liang and TAN Jian-ming |
| Institution: | HOU Ming-ming1,2,SONG Hong-tao1,WANG Qing-hua3,YANG Shun-liang3,TAN Jian-ming3(1.Department of Pharmacy,Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350025,China,2.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,3.Department of Urology,China) |
| Abstract: | Objective To investigate the impact of MDR1C3435T genetic polymorphism on the concentration/dose(C/D) ratio,acute rejection and adverse effect of tacrolimus(FK506)in the renal patients after transplantation.Methods The MDR1C3435T genotype was determined by PCR-RFLP method.The differences of C/D ratio,acute rejection and adverse reaction were compared among all of the genotype groups treated with FK506.Results There was no significant difference in the C/D ratio,rejection and adverse reaction of FK506 among ... |
| Keywords: | MDR1 |
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