Microdialysis: a way to study in vivo release of neurotrophic bioactivity: a critical summary |
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| Authors: | C. Humpel T. Ebendal L. Olson |
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| Affiliation: | (1) Neurochemistry Unit, Department of Psychiatry, Anichstrasse 35, A-602 Innsbruck, Austria;(2) Department of Developmental Neurosciences, University of Uppsala, Sweden;(3) Department of Neuroscience, Karolinska Institute, Stockholm, Sweden |
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| Abstract: | Microdialysis has been proven to be a valuable tool to study in vivo release of various neurotransmitters in the rat brain. Recently we demonstrated for the first time the release of neurotrophic bioactivity in the brains of awake rats. Neurotrophic factors, however, exist in extremely low concentrations in the brain compared to neurotransmitters, rendering their detection particularly difficult. This review summarizes knowledge about the use of microdialysis for the detection of neurotrophic bioactivity, its limits, and its problems.Abbreviations BDNF Brain-derived neurotrophic factor - EIA Enzyme immunoassay - NGF Nerve growth factor - NT-3 Neurotrophin-3 |
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| Keywords: | In vivo Microdialysis Release Secretion Trophic factors |
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