Mapping of gene loci in the Q13–Q15 region of chromosome 12 |
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| Authors: | Erika L D Mitchell Gavin R M White Mauro F Santibanez-Koref Jenny M Varley Jim Heighway |
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| Institution: | (1) the Cancer Research Campaign Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, M20 9BX Manchester, UK |
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| Abstract: | The gene loci CDK4, GLI, CHOP and MDM2 have been mapped to the q13–q15 region of chromosome 12. Using fluorescencein situ hybridization onto simultaneously DAPI-banded metaphase chromosomes and interphase nuclei, we have more precisely mapped and ordered these loci, together with a number of Genethon microsatellite markers. GLI and CHOP localize to 12q13.3–14.1, CDK4 to 12q14 and MDM2 to 12q14.3–q15, and the gene order is cen-GLI/CHOP-CDK4-MDM2. The Genethon microsatellites D12S80 and D12S83 flank MDM2. |
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| Keywords: | chromosome 12 gene mapping 12q13– q15 |
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