Cyclin D1在增生性子宫内膜及子宫内膜癌中的表达及意义

目的: 探讨细胞周期素D1 (Cyclin D1)蛋白在增生性子宫内膜及子宫内膜癌中的表达及意义.方法: 用免疫组化SP法对14例正常子宫内膜,25例增生性子宫内膜及43例子宫内膜癌中Cyclin D1表达进行了研究.结果: 正常子宫内膜、单纯加复合增生、不典型增生及子宫内膜癌中Cyclin D1阳性率分别为14.3%, 43.8%, 77.8%, 72.1%.增生性子宫内膜、子宫内膜癌与正常内膜有显著性差异(P<0.05),不典型增生与单纯加复合增生Cyclin D1过表达有显著性差异(P<0.05);子宫内膜癌Cyclin D1过表达阳性率与癌细胞分化程度有关,与组织学类型无关.结论: Cyclin D1异常参与子宫内膜癌的发生,其过表达与子宫内膜癌的恶性生物学行为有关,对内膜癌Cyclin D1蛋白表达的检测有助于估计其进展及预后.

Expression of Cyclin D1 in proliferative endometrium and endometrial carcinoma and its significance

AIM: To investigate the expression of Cyclin D 1 in proliferative endometrium and endometrial carcinoma and its significance. METHODS: Expression of Cyclin D 1 was examined in 14 cases of normal endometrium, 25 cases of proliferative endometrium and 43 cases of endometrial carcinoma by immunohistochemical SP methods. RESULTS: The positivity rate of Cyclin D 1 in normal endometrium, simple and compound hyperplasia, atypical hyperplasia and endometrium carcinoma was 14.3%, 43.8%, 77.8% and 72.1% respectively. The expression of Cyclin D 1 in proliferative endometrium and endometrial carcinoma was significantly higher than that in normal endometrium ( P < 0.05). The overexpression of Cyclin D 1 in the atypical hyperplasia group was obviously different from that in the simple and compound hyperplasia group ( P <0.05). In endometrial carcinoma, the overexpression of Cyclin D1 was significantly associated with pathological grade and no association was found with the histologic type of endometrial carcinoma. CONCLUSION: Aberrant expression of Cyclin D 1 was involved in the genesis of endometrial carcinoma. The overexpression of Cyclin D 1 correlate with the malignant biological behaviour of endometrial carcinoma. Detection of the expression of Cyclin D 1 protein in endometrial carcinoma is likely to be predictive of its development and prognosis.