Baclofen antagonism by 2-hydroxy-saclofen in the cat spinal cord |
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| Authors: | D R Curtis B D Gynther D T Beattie D I Kerr R H Prager |
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| Affiliation: | Neuropharmacology Research Group, John Curtin School of Medical Research, Canberra, A.C.T., Australia. |
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| Abstract: | When administered microelectrophoretically, a sulphonic acid derivative of baclofen, 3-amino-2-(4-chlorophenyl)-2-hydroxy-propylsulphonic acid, reversibly reduced the presynaptic reduction by (-)-baclofen of the monosynaptic excitation of spinal interneurones by impulses in low threshold primary afferent fibres of the cat as well as the postsynaptic depression by (-)-baclofen of the firing of these neurones. This compound, 2-hydroxy-saclofen, may be useful in assessing the physiological significance of central baclofen receptors. |
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