血清总胆汁酸测定在肝病诊断中的临床意义

目的：探讨血清总胆汁酸（TBA）测定在各种肝病诊断中的临床应用价值。方法：采用循环酶法测定168例肝病患者的空腹血TBA水平。结果：血清TBA水平在急性肝炎、慢性活动性肝炎、重症肝炎、肝硬化、肝癌、脂肪肝、酒精性肝炎患者中明显升高，其阳性率分别为90．9％、89．2％、100％、100％、100％、41．7％、47．4％。升高的程度与肝病的严重程度相一致。结论：血清TBA的测定可以作为反映急慢性肝病、肝硬化严重程度和预后的指标。

CLINICAL SIGNIFICANCE OF TOTAL SERUM BILE ACID IN DIAGNOSIS OF LIVER DISEASES

Objective:To study clinical significance of total serum bile acid in diagnosis of liver diseases.The level of total bile acid(TBA) in serum was a sensitive index to reflect damage of liver.Methods:The level of total serum bile acid was measured in 168 patients with various liver diseases by circular enzyme method.Results:Compared with that in normal subjects ,the level of total serum bile acid was significantly high in patients with acute hepatitis,chronic activated hepatitis,serious hepatitis,cirrhosis of liver,liver cancer,fatty hepatitis , and ethanol hepatitis,with positive rates of TBA being 90 9%,89 2%,100%,100%,100%,41 7% and 47 4% respectively.The total serum bile acid level was positively correlated with the severity of hepatic diseases.Conclusion:Measurement of total serum bile acid may be useful for assessment of the degree and prognosis of acute or chronic hepatic diseases and cirrhosis of liver.