肝硬化合并感染的临床与危险因素分析

目的探讨肝硬化患者合并感染的情况及危险因素。方法回顾性分析2002年1月-2004年12月在某院住院的120例肝硬化患者病历资料。结果其中60例（50.00％）继发感染的患者，28例（46.67％）感染发生在医院内；13例感染患者死亡，病死率21．67％，显著高于无感染患者的病死率3．33％（X^2=9．219，P〈0.01）。最常见感染为自发性腹膜炎，共35例次（57.38%），其次为肠道感染12例次（19.67％），肺部感染10例次（16．56％）。送标本培养40例，12例（30．00%）阳性，其中检出革兰阴性菌者10例（83.33％）。血清清蛋白水平和住院时间是肝硬化患者发生感染的独立危险因素。结论肝硬化患者感染发生率高，而发生感染者病死率高；其危险因素为低蛋白血症及住院时间过长。

Analysis on clinical and risk factors of infection associated with hepatocirrhosis

Objective To evaluate risk factors of infection associated with hepatocirrhosis. Methods Clinical data of 120 patients who were hospitalized in a hospital from January 2002 to December 2004 were analysed retrospectively. Results Sixty of 120 （50. 00%） patients developed secondary infection, 28 （46.67%） of whom were nosocomial infection; 13 patients died, the mortality was 21.67%, which was obviously higher than 3. 33% of patients without nosoeomial infection, （X^2 = 9. 219, P〈0. 01） . The most common infection was spontaneous peritonitis, which was 35 （57.38%） cases, 12 cases （19.67 %） were intestinal tract infection, 10 （16.56%） were lung infection. Samples of 40 patients were send for detection, 12 （30. 00%） were positive, 10 of 12 （83. 33%） patients were detected gram- negative bacteria. The risk factors for the occurrence of infection in patients with hepatocirrhosis were level of serum albumin and length of hospitalization. Conclusion The occurrence of infection in patients with hepatoeirrhosis is high, the mortality in infected patients is also high; the risk factors are hypoalbuminemia and long length of hospitalization.