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| 流化床包衣法制备芍药总苷缓释微丸的研究 | |
| 引用本文： | 陈丽华,徐德生,冯怡,洪燕龙,汪益涵.流化床包衣法制备芍药总苷缓释微丸的研究[J].中草药,2009,40(3):379-383. |
| 作者姓名： | 陈丽华 徐德生 冯怡 洪燕龙 汪益涵 |
| 作者单位： | 1. 江西中医学院,现代中药制剂教育部重点实验室,江西,南昌,330004 2. 上海中医药大学附属曙光医院,上海,200021 3. 上海中医药大学,上海,201203 |
| 基金项目： | ,上海市重点学科建设项目,上海市科委项目,高等学校博士学科点专项科研基金 |
| 摘 要： | 目的 应用挤出滚圆法制备芍药总苷速释微丸,用Eudragit RS 100作为包衣材料,制备芍药总苷缓释微丸.方法 采用mini Glatt流化床底喷包衣法制备缓释微丸,对其包衣工艺及处方进行单因素考察.评价微丸的粉体学性质和体外释放行为.结果 当聚合物包衣增质量为6%,增塑剂用量为10%时,药物具有明显的缓释作用,体外释放曲线符合Peppas和Higuchi方程.结论 制备的芍药总苷缓释微丸具备较理想的缓释效果. |
| 关 键 词： | 芍药总苷缓释微丸 Eudragit RS 100 缓释微丸 释放度 |
| 收稿时间： | 2008/5/20 0:00:00 |
Preparation of total glucosides in paeony sustained-release pellets by fluidized bed coating method |
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| CHEN Li-hu,XU De-sheng,FENG Yi,HONG Yan-long and WANG Yi-han.Preparation of total glucosides in paeony sustained-release pellets by fluidized bed coating method[J].Chinese Traditional and Herbal Drugs,2009,40(3):379-383. | |
| Authors: | CHEN Li-hu XU De-sheng FENG Yi HONG Yan-long and WANG Yi-han |
| Institution: | Key Laboratory for Modern Preparation of Traditional Chinese Medicine,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China |
| Abstract: | Objective To prepare totel glucosides in paeony(TGP) pellets by extrusion-spheronization and to optimize the formulation of TGP sustained-release pellets coated with Eudragit RS 100.Methods The TGP sustained-release pellets were prepared by mini Glatt fluidized bed coating method.The factors to influence the drug release behaviors and their properties were evaluated.Results The optimal TGP sustained-release pellet was shown significant sustained-releasing at the loading weight of copolymers of 6% and the plasticizer concentration of 10%.And the curves of cumulative drug release were fit for Peppas and Higuchi equation.Conclusion The pellets showed an obviously sustained-release effect. |
| Keywords: | totel glucosides of paeony ( TGP) sustained-release pellets Eudragit RS 100 sustained-release pellets dissolution |
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