FoxP3 rs3761548 polymorphism predicts autoimmune disease susceptibility: A meta-analysis |
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Authors: | Yanqi He Huang Na Yalun Li Zhixin Qiu Weimin Li |
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Institution: | 1. Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China;2. Department of Respiratory Medicine, The First Affiliated Hospital to Chengdu Medical College, Chengdu 610041, China |
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Abstract: | Background and aimsAutoimmune diseases (ADs) are associated with loss of self-tolerance leading to immune-mediated destruction of host tissues and organs. FoxP3 polymorphism (−3279 A/C, rs3761548) was shown to associate with AD susceptibility, but the results were inconsistent. This study performed a meta-analysis to investigate the FoxP3 −3279 A/C polymorphism for AD susceptibility.MethodsA total of eight published case-control studies, including 1844 cases and 1857 controls were retrieved from the PubMed database for the meta-analysis. Heterogeneity was assessed with a standard Q-statistic test and I2 test. Crude pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the FoxP3 polymorphism and AD risk according to the random-effective model and fixed-effective model.ResultsA significant relationship between FoxP3 −3279 A/C gene polymorphism and ADs was found under the allelic (OR: 1.477, 95% CI: 1.326–1.645, P = 0.000), homozygous (OR: 2.094, 95% CI: 1.390–3.153, P = 0.000), recessive (OR: 1.804, 95% CI: 1.083–3.008, P = 0.024), dominant (OR: 1.323, 95% CI: 1.154–1.516, P = 0.000), and additive (OR: 1.516, 95% CI: 1.360–1.689, P = 0.000) genetic models. However, there was no significant association between FoxP3 −3279 A/C polymorphism and ADs under the heterozygous genetic model (OR: 1.202, 95% CI: 0.899–1.606, P = 0.215).ConclusionFoxP3 −3279 A/C polymorphism may influence AD risk, especially, the A allele variant carriers of FoxP3 −3279 A/C polymorphism definitively associated with AD susceptibility. |
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