Association of IL-8 gene polymorphisms with non small cell lung cancer in Tunisia: A case control study |
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| Authors: | Ahlem Rafrafi Besma Chahed Safa Kaabachi Wajih Kaabachi Haifa Maalmi Kamel Hamzaoui Fayçal Haj Sassi |
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| Institution: | Homeostasis and Cell Dysfunction Unit Research 99/UR/08-40, Faculty of Medicine, University of Tunis El Manar II, Tunis 1007, Tunisia |
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| Abstract: | Interleukin 8 (IL-8), is a proinflammatory chemokine, has been reported to have angiogenic activity and to be responsible for tumor-associated angiogenesis in several cancers. In this study, we aimed to study the (IL-8) gene polymorphism in relation with risk development of non small cell lung cancer in Tunisian patient. Two single nucleotide polymorphisms (−251T/A rs4073], +781C/T rs2227306]) of the IL-8 gene were screened in 170 patients with NSCLC and 225 healthy controls by PCR–RFLP. |
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