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MAPT gene rs1052553 variant is not associated with the risk for multiple sclerosis |
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| Authors: | José AG Agúndez Elena García-Martín Carmen Martínez Julián Benito-León Jorge Millán-Pascual Patricia Calleja María Díaz-Sánchez Diana Pisa Laura Turpín-Fenoll Hortensia Alonso-Navarro Lucía Ayuso-Peralta Dolores Torrecillas José Francisco Plaza-Nieto Félix Javier Jiménez-Jiménez |
| Institution: | 1. Department of Pharmacology, University of Extremadura, Cáceres, Spain;2. Department of Biochemistry and Molecular Biology, University of Extremadura, Cáceres, Spain;3. CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Spain;4. Service of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain;5. Department of Medicine, University Complutense, Madrid, Spain;6. Section of Neurology, Hospital La Mancha-Centro, Alcázar de San Juan, Ciudad Real, Spain;g Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma, Cantoblanco, 28049 Madrid, Spain;h Department of Medicine-Neurology, Hospital “Príncipe de Asturias”, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain;i Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey E-28500, Madrid, Spain |
| Abstract: | Background/ObjectivesSome experimental data suggest a possible role of tau protein in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis. The aim of this study was to investigate a possible influence of the SNP rs1052553 in the MAPT gene in the risk for relapsing bout onset (relapsing–remitting and secondary progressive) MS.MethodsWe analyzed the allelic and genotype frequency of MAPT rs1052553, which has been associated with some neurodegenerative diseases, in 259 patients with relapsing bout onset MS and 291 healthy controls, using TaqMan Assays.ResultsMAPT rs1052553 allelic and genotype frequencies did not differ significantly between relapsing bout onset MS patients and controls, and were unrelated with the age of onset of MS or gender.ConclusionsThese results suggest that MAPT rs1052553 polymorphism is not related with the risk for relapsing bout onset MS. |
| Keywords: | MS multiple sclerosis GWAS genome-wide association studies TNFRSF1A tumor necrosis factor receptor superfamily member 1A CSF cerebrospinal fluid TPPP/p25 tubulin polymerization promoting protein 25 MAPT microtubule-associated protein tau SNP single nucleotide polymorphism |
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