| 右旋美托咪啶对大鼠脑外伤后炎症反应的干预作用 |
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| 引用本文： | 杨能力,徐道妙,明广峰,马新华.右旋美托咪啶对大鼠脑外伤后炎症反应的干预作用[J].实用预防医学,2010,17(2):243-245. |
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| 作者姓名： | 杨能力 徐道妙 明广峰 马新华 |
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| 作者单位： | 中南大学湘雅医院ICU,湖南,长沙,410008 |
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| 摘 要： | 目的探讨中枢性α2肾上腺素受体激动剂-右旋美托咪啶(dexmedetomidine,DEX)对大鼠创伤性脑外伤(traumatic brain injury,TBI)后神经保护作用及其机制。方法60只雄性SD大鼠随机均分为正常对照组(C组)、假手术组(SHAM组)、脑外伤组(TBI组)、右旋美托咪啶治疗组(DEX组)。采用自由落体硬膜外撞击法建立局灶重度脑创伤模型,用ELISA法检测各组脑组织在伤后6、24、72h神经元特异性烯醇化酶(neurone specificenolase,NSE)、血清肿瘤坏死因子-α(tumor necrosis factor-alpha,TNF-α)和白细胞介素-6(Interleukin-6,IL-6)的含量。结果在伤后6、24、72h,DEX组脑组织NSE较TBI组明显减少(P0.05),血清炎症因子TNF-α明显降低(P0.05),在伤后6、72h,DEX组血清IL-6较TBI组明显降低(P0.05)。结论右旋美托咪啶对大鼠脑外伤后早期有神经保护作用,其作用机制可能与减轻炎症反应有关。
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| 关 键 词： | 中枢性α_2肾上腺素受体激动剂 脑损伤 神经保护 NSE 炎症 |
Intervention Effect of Dexmedetomidine on Inflammatory Response Following Traumatic Brain Injury in Rats |
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| YANG Neng-li,XU Dao-miao,MING Guang-feng,et al..Intervention Effect of Dexmedetomidine on Inflammatory Response Following Traumatic Brain Injury in Rats[J].Practical Preventive Medicine,2010,17(2):243-245. |
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| Authors: | YANG Neng-li XU Dao-miao MING Guang-feng |
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| Institution: | YANG Neng-li,XU Dao-miao,MING Guang-feng,et al.(Department of ICU,Xiangya Hospital of Central South University,Changsha 410008,Hunan,China) |
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| Abstract: | Objective To investigate the neuroprotective effect of alpha 2-adrenergic agonist (dexmedetomidine,DEX) on traumatic brain injury (TBI) in rats.Methods Sixty male Sprague-Dawley (SD) rats were randomly divided into normal control group,sham operation group,TBI group,and DEX group,each of which was subgrouped at 6,24,and 72 hours.Parietal brain contusion was produced by a free-falling weight on the exposed dura of the left parietal lobe.Neurone specific enolase (NSE) activity in the injured brain tissue and ... |
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| Keywords: | NSE |
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