Effects of perioperative cimetidine administration on natural killer cells in patients with gastrointestinal cancer |
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Authors: | Yan Li De-jiao Bai Kun Wang Guo-liang Yang Hong-yin Yuan Hua Shao |
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Institution: | (1) Department of Oncology, the 2nd Affiliated Hospital, Hubei Medical University, No. 169, Donghu Road, Wuchang District, 430071 Wuhan, China;(2) Department of Laboratory, the 2nd Affiliated Hospital, Hubei Medical University, 430071 Wuhan, China |
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Abstract: | Objective: To study the effects of perioperative use of cimetidine on natural killer (NK) cells in gastrointestinal (GI) cancer
patients. Methods: 49 GI cancer patients were randomized into treatment group which took cimetidine in the perioperative period,
and control group which did not take the drug. NK cells were measured by immunocytochemical method, using mouse-anti-human
CD57 monoclonal antibody as the primary antibody. Blood samples from 20 healthy volunteers were treated in the same way as normal
control. Comparisons were made within and between groups. Results: The NK cell percentage of normal control was 18.50±2.31.
Both groups of patients had significantly lower than normal NK percentages before treatment (P<0.05). NK cell percentages at admission, before operation, on the 2nd and the 10th postoperative days were 14.60±3.91, 15.64±3.61,
17.40±3.28, 20.68±4.13, respectively, for the treatment group, and 14.88±2.76, 13.17±2.93, 14.50±2.77, 15.67±2.55, respectively,
for control group. The difference between the two groups was statistically significant. Conclusion: Perioperative cimetidine
application can help restore NK cells. The drug may be useful to reverse postoperative immuno-depression in GI cancer patients. |
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Keywords: | Cimetidine Natural killer cells Gasstrointestinal cancer |
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