不同剂量川芎嗪对兔背缺血皮瓣的作用

目的:寻找川芎嗪对缺血皮瓣发挥保护作用的合适剂量。方法:家兔16只随机分为4组,于兔背部设计8 cm×2 cm任意皮瓣,切取、剥离后原位缝合。对照组(A组)予以0.9%氯化钠注射液4 ml/kg,术后用药组分别予以川芎嗪15、30、60 mg/kg(B、C、D组)。术后第7天处死白兔,测量皮瓣成活面积,分析不同剂量的川芎嗪与皮瓣成活之间的关系。结果:术后第7天皮瓣远端均发生坏死,近端成活。随药物剂量增加,C、D组皮瓣成活面积及成活率均高于A、B组(P<0.05～P<0.01);A组与B组和C组与D组皮瓣成活面积及成活率差异均无统计学意义(P>0.05)。结论:适当剂量使用川芎嗪治疗可提高局部缺血皮瓣的成活率。

The effect of different dosages of ligustrazine on the ischemic skin flap of rabbit back

Objective:To investigate the suitable dosages of ligustrazine with good protective effect on ischemic skin flap. Methods:The Japanese big ear white rabbits were randomly divided into four groups. The 8 cm × 2 cm random flap in the rabbit back was designed,cut and stripped,and the rabbits were stitched in situ. Group B,C and D were treated with 15,30 and 60 mg/kg of ligustrazine after operation,respectively,and the group A were treatment with 4 ml/kg of 0. 9% sodium chloride injection. Rabbits were sacrificed after 7 days of operation, the flap survival area was measured, the relationship between different concentrations ligustrazine and flap survival was analyzed. Results:The distal necrosis and proximal survival of flap was found after days 7 operation. With the increasing of drug dosages,the flap survival area and average survival rate increased. The flap survival area and average survival in group C and D were higher than those in group A and B(P<0. 05 to P<0. 01),the differences of which between group A and B,and between group C and D were not statistically significant(P >0. 05). Conclusions:Appropriate dose of ligustrazine can improve the survival rate of ischemic skin flap.