胰岛素泵在2型糖尿病强化治疗中的疗效观察

目的:观察胰岛素泵在2型糖尿病强化治疗中的疗效和安全性。方法:将40例2型糖尿病患者随机分为对照组和治疗组各20例。对照组予诺和灵R三餐前+甘精胰岛素睡前皮下注射,治疗组予胰岛素泵连续皮下注射超短效赖脯胰岛素。记录2组患者治疗前后空腹、餐后2 h血糖值,血糖达标时间、胰岛素用量及低血糖发生率。结果:2组空腹血糖值、餐后2 h血糖值均较治疗前明显下降(PP>0.05)。2组胰岛素用量差异有统计学意义(PP>0.05)。结论:胰岛素泵连续皮下注射较符合生理需求,血糖控制佳,低血糖发生率低,是值得推广的糖尿病治疗方法。

Clinical effects of insulin pump in intensive treatment of type 2 diabetes mellitus

Objective:To observe the curative effect and safety of insulin pump in intensive treatment of type 2 diabetes mellitus. Methods:Forty patients with type 2 diabetes mellitus were randomized to control group and treatment group. The control group were injected Novolin R before meals and insulin glargine at bedtime,while the treatment group received continuous subcutaneous insulin infusion with ultra-short-acting insulin lispro. The fasting blood glucose level,2-hour postprandial blood glucose,the time when blood glucose reached the standard,the dosage of insulin and the incidence of hypoglycemia of the patients in each group were respectively recorded before and after treatment. Results:The fasting blood glucose level and 2-hour postprandial blood glucose in both groups decreased obviously(P<0. 01). The contrast differences between the results of the two groups were not statistically significant(P>0.05).The contrast differences in the dosage of insulin were statistically significant(P <0. 01). The contrast differences in the incidence of hypoglycemia were not statistically significant(P>0. 05). Conclusions:Insulin pump continuous infusion is consistent with the physiological situation and good for controlling the blood glucose and lowering the incidence of hypoglycemia. This therapy is worth popularizing for treatment of diabetes mellitus.