黄连素对新诊断2型糖尿病患者内皮功能、白介素-6、肿瘤坏死因子-a的影响

目的探讨黄连素对新诊断2型糖尿病（T2DM）患者内皮细胞功能、白介素-6（IL-6）、肿瘤坏死因子-a（TNF—a）的影响。方法选取60例新诊断为T2DM的患者作为治疗组，随机分为两组，每组30人，分别给予黄连素联合胰岛素治疗及单纯胰岛素治疗，检测两组患者治疗前后血糖水平、血管性假血友病因子（vwF）、血栓调节蛋白（TM）和内皮细胞蛋白C受体（EPCR）、白介素-6（IL-6）、肿瘤坏死因子-a（TNF—a）水平，并与对照组（体检健康人群n=30）相应指标进行比较。结果治疗前黄连素组和单纯胰岛素组的空腹血糖、餐后血糖、糖化血红蛋白、VwF、TM、EPCR、IL-6、TNF—a差异无统计学意义，治疗前黄连素组和单纯胰岛素组的VwF、TM、EPCR、IL-6、TNF-a均高于对照组（P〈0．05）；黄连素组和单纯胰岛素组治疗后的空腹血糖、餐后血糖、糖化血红蛋白、VwF、TM、EPCR、IL-6、TNF—a低于治疗前（P〈0．05）；治疗后黄连素组和单纯胰岛素组的空腹血糖、餐后血糖、糖化血红蛋白差异无统计学意义，治疗后黄连素组的VwF、EPCR、IL-6低于单纯胰岛素组（P＜0．05）。结论黄连素能够通过抑制炎症因子对2型糖尿病患者的血管内皮功能起到更好的保护作用。

Research on the Effect of Berberine on the Function of Endothelial Vessels, IL-6 and TNF-a in Newly Diagnosed Patients with Type 2 Diabetes Mellitus

Objective To explore the effect of berberine on the function of endothelial vessels, IL-6 and TNF-a in newly diagnosed patients with type 2 diabetes mellitus. Methods 60 patients newly diagnosed with type 2 diabetes patients were selected as treatment group, half of them treated by insulin combined with berberine, others only treated by insulin. Glucose level, vascular false hemophilia factor （VWF）, blood clots regulatory proteins （TM） and endothelial cell protein C receptor （EPCR） level in all patients were detected before and after the treatment, comparing with the control group （n=30）. Results Before treatment, VWF, TM, EPCR, IL-6 and TNF-a of all the patients were significantly higher than those of control group （P〈0.05）, while the fasting blood glucose, postprandial blood glucose, HbA1c, VWF, TM, EPCR, IL-6 and TNF-a in patients treated by insulin combined with berberine were not different from those of patients only treated by insulin. After treatment, fasting blood glucose, postprandial blood glucose , HbA1c, VWF, TM, EPCR, IL-6 and TNF-a of all the patients obviously lower than those of before treatment （P〈0.05）, and the fasting blood glucose, postprandial blood glucose and HbA1c in patients treated by insulin combined with berberine also had no difference from those of patients only treated by insulin. However, after treatment with berberine and insulin, VWF, EPCR and IL-6 were lower than those of patients with only insulin （P〈0.05）. Conclusion Berberine can inhibit inflammatory factor to protect the endothelial function of vessels in type 2 diabetes,