1494例社区居民代谢综合征现状调查及与糖化血红蛋白相关性研究

目的调查南昌社区居民20岁以上人群代谢综合征（MS）患病情况，探讨MS与糖化血红蛋白（HbA1C）的关系。方法于2008-2009年，在南昌市13个社区，采用单纯随机抽样方法选择1494例20岁以上长住社区居民为研究对象，进行流行病学问卷调查和体格检查，同时测定空腹血糖（FPG）、餐后2h血糖（2hPG）、HbA。血清胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL—C）、血尿酸（UA）、丙氨酸氨基转移酶（ALT）、门冬氨酸氨基转移酶（AST）等。结果本调查南昌社区人群MS、糖尿病（DM）、高血压（HBP）、超重和（或）肥胖、高三酰甘油血症、高胆固醇血症、低高密度脂蛋白血症、高低密度脂蛋白血症标化患病率分别为11．2％、8．4％、29．5％、25．5％、22．5％、20．3％、1．4％、13．3％。增龄、DM家族史、高血糖、高血压、超重和（或）肥胖、高三酰甘油血症及低高密度脂蛋白血症是MS的危险因素。MS与HbA1C水平呈正相关（r=0．319，P〈0．01），HbA1C≥6．5％的人群MS患病率高达50．34％。结论本研究南昌社区人群具有较高的MS相关疾病的患病率；对HbA1C较高的社区居民应加强筛查，以加强对MS及相关疾病的防治。

The Status Survey of Metabolic Syndrome among 1 494 Residents in Nanchang Community Populations and its Relationship with Glycosylated Hemoglobin

Objective To investigate the prevalence and epidemic of metabolic syndrome （MS） and its relationship with glycosylated hemoglobin among residents aged over 20 yrs in Nanchang community populations. Methods With simple random sampling method, 1 494 permanent residents aged over 20 yrs were selected from 13 communities of Nanchang during 2008-- 2009. A questionnaire survey and medical examination were conducted. The fasting plasma glucose （FPG）, postprandial blood glucose （2hPG）, cholesterol （TC）, triglycerides （TG）, high density lipoprotein-C （HDL-C）, low density lipoprotein-C （LDL-C）, blood pressure （BP） and body mass index （BMI）, uric acid （UA）, glutamic-pyruvic transaminase （ALT）, glutamic-oxaloacetie transaminase （AST） were measured. Results The standardized prevalence rates of MS, diabetes mellitus （DM）, hypertension, overweight, （obesity）, hypertrigtyceridemia, hypercholesterolemia, hypo-high density-lipoproteinemia and hyper-low density- lipoproteinemia in Nanchang community populations were 11.2%, 8.4%, 29.5%, 25.5%, 22.5%, 20.3%, 1.4% and 13.3%, respectively. Age, family history of diabetes, obesity, high blood glucose, hypertension, high triglycerides and low high-density lipoprotein were risk factors for MS. Metabolic syndrome and glycosylated hemoglobin levels were positively correlated. The rate of metabolic syndrome in people with glycosylated hemoglobin≥ 6.5% was 50.34%. Conclusion Nanehang community population in this study has a high MS prevalence. We should strengthen the prevention and treatment of MS and related diseases in the community and pay attention to screen the people with higher glycosylated hemoglobin for MS and its related diseases.