胆固醇与动脉粥样硬化性血管病变的研究

目的：观察血脂对血液流变学的影响，探讨胆固醇与动脉粥样硬化性血管病变之间的关系。方法：选择年龄40～60岁者200人，进行血脂和血液流变学检测，按血脂异常判断标准分为正常血脂、高胆固醇血症、高三酰甘油血症和混合型高脂血症四组，对四组的血液流变学指标进行组间比较。结果：高胆固醇血症组和高三酰甘油血症组的全血粘度比正常血脂组增高（P〈0．001）；高三酰甘油血症组和混合型高脂血症组比高胆固醇血症组的血细胞压积和血浆粘度增高（P〈0．05）。结论：血脂水平与全血粘度成正比，总胆固醇水平与动脉粥样硬化程度呈正相关，胆固醇致动脉粥样硬化作用是缺血性心脑血管疾病的主要危险因素。

Releationship between serum cholesterol and atherosclerotic vascular disease

Objective:To study the effect of blood lipid on hemorheology and the correlation between cholesterol and atherosclerotic disease.Methods:200 persons of 40-60 years old were measured blood lipid and hemorheology,the subject were divided into four groups by index of blood lipid,abnormality: hypercholesterolemia group,hypertriglyceripidemia group,Combined hyperlipidemia group and normal group.Then indexes of hemorheology were compared among the four groups.Results: the whole Blood viscosity of hypercholesterolemia group and hypertriglyceripidemia was significantly higher than normal group(P<0.001);hematocrit and plasma viscosity of hypercholesterolemia group and combined.Hyperlipidemia were significantly higher than hypercholesterolemia(P<0.05).Conclusions: The level of blood lipid is directly proportional to whole blood riscosity.The positively correlation were found out between the total cholesterol and the severity of the arteriosclerosis,the role of hyperclolesterolemia in atherosclerosis is a major risk factor of ischemic Cardio-cerebrovascular diseases.