Changes in purines concentration in the cerebrospinal fluid of patients experiencing pain: A case-control study |
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| Authors: | André P Schmidt Ana Elisa Böhmer Félix A Soares Irimar P Posso Sheila B Machado Florentino F Mendes Luis Valmor C Portela Diogo O Souza |
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| Institution: | 1. Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil;2. Department of Anesthesia and Perioperative Medicine, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil;3. Disciplina de Anestesiologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, SP, Brazil;4. Departamento de Cirurgia da Faculdade de Medicina da Universidade Federal de Ciências da Saúde de Porto Alegre, Brazil |
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| Abstract: | This study analyzes the relationship between extracellular purines and pain perception in humans. Cerebrospinal fluid (CSF) levels of purines and their metabolites were compared between patients displaying acute and/or chronic pain syndromes and control subjects. The CSF levels of IMP, inosine, guanosine and uric acid were significantly increased in the chronic pain group and correlated with pain severity (P < 0.05). Patients displaying both chronic and acute pain presented similar changes in the CSF purines concentration (P < 0.05). However, in the acute pain group, only CSF inosine and uric acid levels were significantly increased (P < 0.05). These findings suggest that purines, in special inosine, guanosine and uric acid, are associated with the spinal mechanisms underlying nociception. |
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| Keywords: | Purines Guanosine Inosine Chronic pain Cerebrospinal fluid Somatic pain |
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