Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals |
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Authors: | Kai Yuan Wei Qin Minghao Dong Jixin Liu Jinbo Sun Peng Liu Yi Zhang Wei Wang Yarong Wang Qiang Li Liyan Zhao Karen M von Deneen Yijun Liu Mark S Gold Jie Tian |
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Institution: | 1. Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi’an 710071, China;2. The Fourth Military Medical University, Xi’an, Shaanxi 710038, China;3. National Institute on Drug Dependence, Peking University, Beijing 100083, China;4. Departments of Psychiatry and Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA;5. Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China |
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Abstract: | Previous neuroimaging studies have demonstrated both structural and functional damages in heroin-dependent individuals. However, few studies investigated gray matter deficits and abnormal resting-state networks together in heroin-dependent individuals. In the present study, voxel-based morphometry (VBM) was used to identify brain regions with gray matter density reduction. Resting-state fMRI connectivity analysis was employed to assess potential functional abnormalities during resting-state. All clinical significances were investigated by examining their association with duration of heroin use. Compared with healthy subjects, heroin-dependent individuals showed significant reduction in gray matter density in the right dorsolateral prefrontal cortex (DLPFC) and a decrease in resting-state functional connectivity between the right DLPFC and left inferior parietal lobe (IPL). The gray matter density of the right DLPFC and its resting-state functional connectivity with the left IPL both showed significantly negative correlation with duration of heroin use, which were likely to be related to the functional impairments in decision-making and cognitive control exhibited by heroin-dependent individuals. Our findings demonstrated that long heroin dependence impairs the right DLPFC in heroin-dependent individuals, including structural deficits and resting-state functional impairments. |
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Keywords: | Heroin Voxel-based morphometry Resting-state |
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