Clinical availability of skin biopsy in the diagnosis of Parkinson's disease |
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| Authors: | Yasuo Miki Masahiko Tomiyama Tatsuya Ueno Rie Haga Haruo Nishijima Chieko Suzuki Fumiaki Mori Mitsuomi Kaimori Masayuki Baba Koichi Wakabayashi |
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| Affiliation: | 1. Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan;2. Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan;3. Department of Neurophysiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan;4. Department of Clinical Pathology, Aomori Prefectural Central Hospital, Aomori, Japan |
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| Abstract: | To determine whether skin biopsy is practically useful in the premortem diagnosis for Parkinson's disease (PD), we examined Lewy pathology in the skin of the chest wall and leg, obtained from 6-mm punch biopsies, using phosphorylated α-synuclein antibody in 20 patients with clinically diagnosed PD. Abnormal accumulation of α-synuclein was found in the chest skin of two (10%) of 20 patients, but not in the leg. Although skin biopsy combined with a conventional immunohistochemistry for α-synuclein is not sufficient as a diagnostic tool, we could firstly demonstrate Lewy pathology in premortem tissue. The skin remains to be a promising tissue to be examined for the premortem diagnosis of PD. |
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| Keywords: | Parkinson's disease Lewy body Phosphorylated α-synuclein Skin Biopsy |
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