The viral TLR3 agonist poly(I:C) stimulates phagocytosis and intracellular killing of Escherichia coli by microglial cells |
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| Authors: | Sandra Ribes Nina Adam Sandra Ebert Tommy Regen Stephanie Bunkowski Uwe-Karsten Hanisch Roland Nau |
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| Affiliation: | 1. Institute of Neuropathology, University of Göttingen, Robert Koch Str. 40, D-37075 Göttingen, Germany;2. Department of Neurology, University of Göttingen, D-37075 Göttingen, Germany;3. Department of Geriatrics, Evangelisches Krankenhaus Göttingen-Weende, D-37075 Göttingen, Germany |
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| Abstract: | Stimulation of murine primary microglia with Toll-like receptor (TLR) agonists enhances their ability to phagocytose and kill bacteria. Here we show that the viral TLR3 agonist poly(I:C) stimulates the release of cyto-/chemokines and nitric oxide by microglia. Poly(I:C) increases microglial phagocytosis and intracellular killing of Escherichia coli K1, a pathogenic encapsulated bacterial strain, after 30 and 90 min of co-incubation. Stimulation with a viral epitope may strengthen the resistance of the brain to bacterial infections in vivo. Our data encourage animal experiments with poly(I:C) derivatives to assess whether this approach can increase the resistance of the CNS against bacterial infections. |
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| Keywords: | Toll-like receptors Poly(I:C) Microglia Escherichia coli Phagocytosis |
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