Different implication of NEDD9 genetic variant in early and late-onset Alzheimer's disease |
| |
Authors: | Andrea Tedde Silvia Bagnoli Irene Piaceri Ersilia Lucenteforte Valentina Bessi Laura Bracco Alessandro Mugelli Sandro Sorbi Benedetta Nacmias |
| |
Affiliation: | 1. Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni, 85 - 50134 Florence, Italy;2. Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy;3. Department of Labour Medicine, Section of Medical Statistics and Biometry, University of Milan, Milan, Italy |
| |
Abstract: | Alzheimer's disease (AD) is a complex and multifactorial progressive neurodegenerative disease. Recently, two studies reported inconsistent results on a possible involvement of the NEDD9 (neural precursor cell expressed, developmentally down-regulated 9, 6p25-p24) as a candidate gene for the risk of developing AD and/or Parkinson's disease (PD). We analyzed the distribution of the rs760678 SNP polymorphism in 735 Italian subjects: 214 unrelated sporadic late-onset AD patients (LOAD, 64.5% females, mean age-at-onset 71.8 ± 5.2 years), 135 early-onset AD patients (EOAD, 57.3% females, mean age-at-onset 57.5 ± 5.5 years) and 386 healthy controls (68.9% females, mean age 83.4 ± 17.9 years; SD). We observed a statistically significant difference between LOAD patients and controls according to genotypes (P = 0.016) and allele frequency (P = 0.007); CC genotype was more frequent in LOAD cases (44.4%) than controls (36.0%). No difference after stratification of the data in terms of gender and status of the APOE ?4 allele was observed. In conclusion, our data do support an implication of the NEDD9 allelic variant in late-onset AD, with an independent effect of the apolipoprotein E (APOE) ?4 allele in the risk of developing AD. |
| |
Keywords: | NEDD9 Alzheimer's disease Genetic variant Apolipoprotein E |
本文献已被 ScienceDirect 等数据库收录! |
|