Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders |
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| Authors: | Yan-Feng Zou Fang Wang Xiao-Liang Feng Wen-Fei Li Jin-Hui Tao Fa-Ming Pan Fen Huang Hong Su |
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| Institution: | 1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China;2. Department of Oncology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China;3. Department of Basic Medical Science, Anhui Medical University, Hefei, Anhui 230032, China;4. Department of Psychiatry, The 4th People''s Hospital of Hefei, Hefei, Anhui 230031, China;5. Department of Rheumatology, Anhui Provincial Hospital, Hefei, Anhui 230001, China |
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| Abstract: | The aim of our study was to assess the association between FKBP5 gene polymorphisms and treatment response in patients with mood disorders using a meta-analysis. Eight separate studies that included data from 2199 subjects were identified. Meta-analysis was performed for three FKBP5 gene polymorphisms (rs1360780, rs3800373, and rs4713916). A significant association of FKBP5 gene rs4713916 polymorphism and response rate was found in patients with mood disorders (Overall: A versus G: OR = 1.28, 95%CI = 1.06–1.53, P = 0.01; GA + AA versus GG: OR = 1.32, 95%CI = 1.05–1.67, P = 0.02. Caucasian: A versus G: OR = 1.28, 95%CI = 1.06–1.55, P = 0.01; GA + AA versus GG: OR = 1.33, 95%CI = 1.04–1.70, P = 0.02). However, we did not detect the association between FKBP5 gene rs1360780 and rs3800373 polymorphisms and treatment response in patients with mood disorders (P > 0.05). This meta-analysis demonstrates that treatment response in patients with mood disorders is associated with FKBP5 gene rs4713916 polymorphism, but not rs1360780 and rs3800373. |
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| Keywords: | Mood disorders FKBP5 Polymorphism Treatment response Meta-analysis |
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