| 温石棉对细胞膜脂质流动性及通透性的影响 |
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| 引用本文： | 吴卫东,刘世杰.温石棉对细胞膜脂质流动性及通透性的影响[J].中华劳动卫生职业病杂志,1994,12(5):267-268. |
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| 作者姓名： | 吴卫东 刘世杰 |
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| 作者单位： | 北京医科大学劳动卫生学教研室 |
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| 摘 要： | 用荧光探针ＤＰＨ标记肺泡巨噬细胞，观察到随温石棉剂量增加，茫棉及涞棉均可增加细胞膜脂质的流动性，表现为膜脂质荧光偏振度及脂区徽粘度的降低。茫棉及涞棉亦可增加膜通透性，使胞内Ｋ＋含量下降，该作用存在剂量一效应关系。茫棉及涞棉所致膜脂质流动性改变与膜通透性改变存在明显相关关系。因此，两种温石棉所致的膜脂质流动性增加可能与膜通透性增加一样与细胞受损有关。
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| 关 键 词： | 温石棉，肺泡巨噬细胞，膜脂质流动性，膜通透性，胞内k＋ |
EFFECTS OF CHRYSOTILE ON LIPID FLUIDTY AND PEABILITY OF ALVEOLAR AM
MACROPHAGE MEMBRANE |
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| Wu Weidong,Liu Shijie,Yin Hong.EFFECTS OF CHRYSOTILE ON LIPID FLUIDTY AND PEABILITY OF ALVEOLAR AM
MACROPHAGE MEMBRANE[J].Chinese Journal of Industrial Hygiene and Occupational Diseases,1994,12(5):267-268. |
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| Authors: | Wu Weidong Liu Shijie Yin Hong |
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| Institution: | Wu Weidong,Liu Shijie,Yin Hong Department of Occupational
Health,Beijing Medical University 100083 |
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| Abstract: | he study dernonstrated that Mangai and
Laiyuan chrysotile could reduce fluorescence polarization and micro-viscosity of alveolar
macrophage membrane labelled with DPH,indicating that chrysotile could increase
membranelipid fluidityv. Both chrysotile could also increase membrane permeability,reduce
the intracellular K content withdose-dependent effect.The increase of membrane lipid fluidity
significantly correlated with that of metnbrane per-meability,suggesting the membrane damage
may be caused by chrysotile. |
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| Keywords: | Chrysotile Alveolar macrophage Membrane lipid fluidity Membrane permeahility Intracelltilar K |
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