接触苯工人白细胞癌基因激活的研究 |
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引用本文: | 夏俊杰 张国高. 接触苯工人白细胞癌基因激活的研究[J]. 中华劳动卫生职业病杂志, 1994, 12(2): 79-82 |
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作者姓名: | 夏俊杰 张国高 |
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摘 要: | 应用PCR-Blot和Dot-Blot技术检测了103名接触苯工人和70名对照组工人外周血白细胞c-Ki-ras2基因和c-myc基因。结果表明,103名接苯者中有4例其外周血白细胞检出c-Ki-ras2基因12位点G→T突变,其接苯工龄在6~10年,而70名对照者未检出该突变;c-Ki-ras2基因12位点(G→A突变在两组工人中均未检出阳性;c-myc基因亦未在两组工人中检出扩增现象。结果提示,c-Ki-ras2基因12位点G→T突变与慢性接触苯有关,有可能是苯白血病发生的分子机理。
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关 键 词: | 苯,癌基因,白血病 |
STUDY ON ACTIVATION OF PROTO-ONCOGEN IN WHITE BLOOD CELLS FROM WORKERS EXPOSED TO BENZENE |
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Abstract: | he mutation,of c-ki-ras2 gene and amplification of c-myc gene were studied in peripheral white blood cells(WBC)from 103 benzene exposed workers and 70 non-exposed workers by PCR-blot or DOt-blot technique. The re-sults indicated that the mutation of 12th codon on exon I of c-ki-ras2 gene may be related to chronic benzene expo-sure and the activation of c-ki-ras2 gene may be the molecular mechanism of leukemia induced by benzene. |
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Keywords: | Benzene Proto-oncogene Leukemia |
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