| ^11C-胆碱在线自动合成和生物体内分布 |
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| 引用本文： | 陈立光 唐安戊 王淑侠 何山震 丁振华. ^11C-胆碱在线自动合成和生物体内分布[J]. 现代临床医学生物工程学杂志, 2005, 11(3): 181-183 |
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| 作者姓名： | 陈立光 唐安戊 王淑侠 何山震 丁振华 |
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| 作者单位： | [1]广东省人民医院核医学科,广州510080 [2]南方医科大学放射医学教研室,广州510515 |
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| 摘 要： | 目的 研究[^11C-甲基]胆碱在线自动化合成的方法，并初步应用于临床试验．方法 ^11C-胆碱柱色层法在线制备，以Wistar大鼠研究动物体内生物学分布．结果 柱色层制备的^11C-胆碱放化纯度大于99％，合成效率为85％，合成时间11 min．动物分布表明：放射性主要分布于肾、肝和肠道，血液清除较快。结论 柱色层法制备^11C-胆碱时间短，效率高，操作简单。
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| 关 键 词： | ^11C-胆碱 生物学分布 自动化合成 柱色层法 |
| 文章编号： | 1008-634X（2005）03-0181-03 |
| 收稿时间： | 2005-04-27 |
| 修稿时间： | 2005-04-27 |
The On-line Automatic Synthesis and Biodistribution of ^11C-Chofine |
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| Chen LiGuang;Tang AnWu;Wang ShuXia;He ShanZhe;Ding ZheHua. The On-line Automatic Synthesis and Biodistribution of ^11C-Chofine[J]. Journal of Modern Clinical Medical Bioengineering, 2005, 11(3): 181-183 |
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| Authors: | Chen LiGuang Tang AnWu Wang ShuXia He ShanZhe Ding ZheHua |
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| Abstract: | Objective To study the on - line automatic synthesis of [ N - methyl -^11C] choline and to apply it in preliminary clinical application. Methods ^11C - Choline has been labeled on - llne with column - method, The biodistribution was studied with Wistar mices. Results The radiochemistry purity was great than 99%, the synthesis yield was 85%. The biodistribution showedt hat most part of activity were in kidney, liver and intestine. Conclusions It is suitable for PET center to synthesize ^11C - choline with column- method because the method has high yield, and operated easily. |
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| Keywords: | ^11C-Choline Biodistribution Automatic synthesis |
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