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Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses |
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| Authors: | Tucker Thomas J Sisko John T Tynebor Robert M Williams Theresa M Felock Peter J Flynn Jessica A Lai Ming-Tain Liang Yuexia McGaughey Georgia Liu Meiquing Miller Mike Moyer Gregory Munshi Vandna Perlow-Poehnelt Rebecca Prasad Sridhar Reid John C Sanchez Rosa Torrent Maricel Vacca Joseph P Wan Bang-Lin Yan Youwei |
| Affiliation: | Departments of Medicinal Chemistry and Structural Biology, Merck Research Laboratories, WP14-3, 770 Sumneytown Pike, P.O. Box 4, West Point, PennsylVania 19486-0004, USA. tom_tucker@merck.com |
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