双水平气道正压通气对急性左心衰患者血浆脑钠素水平的影响

选取2011年1月-2013年12月我院急诊室收治的急性左心衰患者122例,采用随机数字方法分为对照组（62例）和观察组（60例）.对照组采用常规治疗,观察组在常规治疗的基础上加入双水平气道正压通气（Bi-PAP）.分别检测并比较两组治疗前、治疗1h和24h后患者的血气分析指标和血浆脑钠素（BNP）水平.治疗24 h内,对照组和观察组分别有12、8例死亡,差异无统计学意义;对照组治疗前、治疗1h、24 h后的BNP值分别为（1040±315）、（995±245）、（570±164） ng/L,观察组治疗前、治疗1h、24h后的BNP分别为（1 080±209）、（962±189）、（490±138） ng/L.观察组BNP治疗1h、24 h后与同组治疗前及对照组相比均显著降低（P＜0.01）.而对照组BNP仅在治疗24h后与同组治疗前相比显著降低（P＜0.01）.

Effects of Bi-level positive airway pressure on the level of B-type natriuretic peptide in patients with acute left ventricular failure

A total of 122 patients with acute left ventricular failure from January 2011 to December 2013 at our hospital were recruited and divided randomly into control group （n =62） and observation group （n = 60）. Control group received conventional therapy and Bi-level positive airway pressure （Bi-PAP） was added along with conventional therapy for observation group. And 12 and 8 patients died in control and observation groups respectively within 24 h after treatment and there was no statistical difference. The BNP levels of the control group pre-treatment and at 1 h and 24 h post-treatment were （1 040 ± 315）, （995 ± 245） and （570 ± 164） ng/L. The BNP levels of observation group pre-treatment and at 1 h and 24 h post- treatment were （1 080 ±209） , （995 ±245） and （490 ± 138） ng/L. BNP of observation group at 1 h and 24 h post-treatment decreased significantly compared with that pre-treatment and control group （P 〈0.01 ）.Only at 24 h post-treatment, the BNP level of control group decreased significantly compared with that pre- treatment （P 〈0.01 ）.