超敏C反应蛋白与急性脑梗死及中国缺血性卒中亚型的关系

回顾分析我院2012年1月至2013年6月收住的216例急性脑梗死（ACI）患者的临床资料。ACI患者血清超敏C反应蛋白（hs-CRP）水平高于186例体检者（4．29±2．30）与（2．13±1．79）mmoVL，P〈0．01]。美国国立卫生研究院卒中量表（NIHSS）评分〉8分的127例ACI患者血清hs—CRP水平高于NIHSS评分≤8分89例患者（5．89±4．15）与（2．11±1．45）mg／L，P〈0．05）]；98例大动脉粥样硬化型患者的hs—CRP水平为（6．32±4．12）mv／L，hs．CRP阳性（〉3mg／L）率为85．7％（84／98），均高于穿支小动脉病变型（1．97±0．86）mg／L，7／71]、心源性栓塞型（3，70±2．76）mg／L，14／24]、不明病因型（3．43±3．52）mg／L，5／11]和其他原因明确型（3．41±3．25）mg／L，5／12]（均P〈0．05）。logistic回归分析高血压病、糖尿病、房颤、吸烟、TC、高同型半胱氨酸及he—CRP与ACI呈正相关（OR值为1．17～3．08，均P〈0．01）。提示ACI患者hs．CRP水平明显增高，且与神经功能缺损程度有关。

Relationship between high sensitive C-reactive protein and stroke subtype according to Chinese Ischemic Stroke Subclassification criteria in patients with acute cerebral infarction

By analyzing the clinical data of 216 cases of acute cerebral infarction （ACI） from 2012 January to 2013 June retrospectively, we found that the serum levels of high sensitive C-reactive protein （hs-CRP） in patients were significantly higher than those in 186 controls （P 〈 0.01 ）. The degree of neural function defect in ACI patients was assessed by the National Institutes of Health Stroke Scale （NIHSS） score. The hs-CRP level of the patients with NIHSS score 〉 8 were higher than that in those with NIHSS score ≤8 （ P 〈 0.05）. The hs-CRP level of patients of large artery atherosclerosis were （6.32 ± 4.12） mg/L and the positive rate of hs-CRP was 85.7% （84/98）. All were respectively higher than those in patients of penetrating artery disease （ 1.97± 0.86） rag/L, 7/71 ], cardiogenic stroke （ 3.70 ± 2.76 ）rag/L, 14/24], undetermined etiology （3.43 ±3.52） rag/L, 5/11 ] and other etiologies （3.41 ±3.25） rag/L, 5/12] （all P 〈0.05 ）. Logistic regression analysis was performed for the risk factors of ACI. The correlative factors of ACI included hypertension, diabetes mellitus, atrial fibrillation, smoking, total cholesterol, homocysteine and high sensitive C-reactive protein （OR = 1.56, 1. 19, 1.23, 1. 17, 3.08, 1.34, 1.25, all P 〈 0.01 ）. The serum levels of hs-CRP increased significantly in ACI patients and were correlated with the degree of neural function defect.