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Gene promoter hypermethylation in ductal lavage fluid from healthy <Emphasis Type="Italic">BRCA</Emphasis>gene mutation carriers and mutation-negative controls |
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| Authors: | Imogen Locke Zsofia Kote-Jarai Mary Jo Fackler Elizabeth Bancroft Peter Osin Ashutosh Nerurkar Louise Izatt Gabriella Pichert Gerald PH Gui Rosalind A Eeles |
| Institution: | (1) Translational Cancer Genetics Team, Institute of Cancer Research, 15 Cotswold Road, SM2 5NG Sutton, Surrey, UK;(2) Department of Cancer Genetics, Royal Marsden NHS Foundation Trust, Fulham Road, SW3 6JJ London, UK;(3) Department of Oncology, Johns Hopkins University School of Medicine, 401 North Broadway, 21231 Baltimore, MD, USA;(4) Department of Pathology, Royal Marsden NHS Foundation Trust, Fulham Road, SW3 6JJ London, UK;(5) Department of Genetics, Guy's and St Thomas' NHS Foundation Trust, St Thomas Street, SE1 9RT London, UK;(6) Department of Surgery, Royal Marsden NHS Foundation Trust, Fulham Road, SW3 6JJ London, UK |
| Abstract: | IntroductionFemale germline BRCA gene mutation carriers are at increased risk for developing breast cancer. The purpose of our study was to establish whether healthy BRCA mutation carriers demonstrate an increased frequency of aberrant gene promoter hypermethylation in ductal lavage (DL) fluid, compared with predictive genetic test negative controls, that might serve as a surrogate marker of BRCA1/2 mutation status and/or breast cancer risk. |
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