瑞舒伐他汀钙联合步长脑心通降脂的疗效和安全性研究

目的评价瑞舒伐他汀钙和步长脑心通联合降脂的疗效和安全性,以及对低密度脂蛋白与高密度脂蛋白比值(LDL-C/HDL-C)和脂蛋白aLp(a)]的干预效果。方法采用随机平行组间对照研究的方法,将筛选合格的136例受试者随机分配为A组68例、B组68例,B组给瑞舒伐他汀钙10 mg,1次/d,A组在B组基础上给步长脑心通4粒,3次/d,连续治疗12周。分别于受试后的第4、8、12周随访。结果两组患者在治疗第4、8、12周后血脂水平均有显著下降(P<0.05),联合治疗效果均优于单用组。两组治疗4周时血脂水平均有下降,但两组差异无统计学意义。治疗8周时,联合治疗组血脂明显下降,且效果优于单用组,差异有统计学意义(P<0.05),治疗12周时,联合治疗组血脂水平下降显著,LDL-C/HDL-C和Lp(a)的水平下降更显著,差异有显著统计学意义(P<0.01)。结论瑞舒伐他汀钙联合步长脑心通可显著降低血脂水平,可显著降低LDL-C/HDL-C和Lp(a)的水平,且有良好安全性。

Research on the effectiveness and safety about Rosuvastatin and Buchang Naoxintong in the treatment of hyperlipidemia

Objective To evaluate the effectiveness and safety about Rosuvastatin and Buchang Naoxintong in the treatment of hyperlipidemia,and the intervention effectiveness on LDL-C/HDL-C and Lp(a).Methods Roanvastatin combined Buchang Naoxintong was used as the experimental drug and Roanvastatin as the control.136 hyperlipidemia patients were enrolled and randomly divided into group A(n=68) and group B(n=68).Patients took Rosuvastatin 10mg and Buchang Naoxintong 4 softgels 3 times daily in group A(n=68) and took Rosuvastatin 10mg in group B(n=68) for 12 weeks.The patients was followed up at the fourth week,eighth week and twelfth week,blood lipid test,liver and kidney function test,blood routine and urine routine were evaluated.Results The lipid levels were decreased at the fourth week,eighth week and twelfth week in each group(P<0.05).Treatment effect in treatment group was better than in control group.The level of lipid decreased in both groups at the fourth week and at the eighth week,the difference has no statistical significance;the effectiveness of group A was better than group B at the eighth week,the difference has statistical significance P<0.05).At the twelfth week,the level of lipid decreased more obviously and LDL-C/HDLC and Lp(a)significantly decreased,the difference has statistical significance P<0.01).Conclusion Rosuvastatin combined with Buchang Naoxintong has an excellent clinical efficacy in treating patients with hyperlipidemia and higher safety,can decrease LDL-C/HDL-C and Lp(a) level.