早中期胃癌患者外周血微转移与红细胞免疫功能的关系

目的探讨早中期胃癌患者外周血CEA-mRNA表达情况与红细胞免疫功能的关系。方法选择早中期胃癌患者40例,根据外周血CEA-mRNA表达情况分为微转移组与无微转移组,分析两组胃癌患者年龄、性别、发病部位、侵犯深度以及Brrmann分型差异,玫瑰花环实验法检测所有患者红细胞免疫C3b受体(C3bR)花环与红细胞循环免疫复合物(ICR)花环百分率等红细胞免疫功能指标。结果微转移组与无微转移组年龄、性别、病理类型、发病部位、侵犯深度以及Brrmann分型等临床特征差别均无统计学意义(P>0.05)。微转移组胃癌患者红细胞免疫C3b受体(C3bR)花环与红细胞循环免疫复合物(ICR)花环百分率均低于无微转移组患者(P<0.05)。结论发生微转移的早中期胃癌患者红细胞免疫功能偏低。

The relationship between the peripheral blood micrometastasis and erythrocyte immunity in patients with early and middle stages of gastric carcinoma

Objective To investigate the relationship of the expression of CEA-mRNA and the erythrocyte immunity in patients with early and middle stages of gastric carcinoma.Methods Forty patients with gastric carcinoma were divided into micrometastasis group and the no micrometastasis group according to the expression of CEA-mRNA.The clinical feature of all patients in two groups,such as age,sex,invasion position,invasion stage and Brrmann category,were all investigated.The erythrocyte C3b receptor garland rate(C3bR) and immune complexes garland rate(ICR) were detected too.Results The difference of clinical feature(such as age,sex,invasion position distribution,invasion stage and Brrmann category) between the micrometastasis group and the no micrometastasis group showed no statistical significance(P>0.05).The rate of C3bR and the ratio of ICR in peripheral blood in patients of in the micrometastasis group were lower than that in the no micrometastasis group(P<0.05).Conclusion The patients of early and middle stages gastric carcinoma with peripheral blood micrometastasis had a lower erythrocyte immune function.